Nutrition for Pets: Navigating Uncharted Waters

Guidance in sepsis management: navigating uncharted waters?

Guidelines can influence physicians to act against their better judgement. For example, while only 47% of surveyed intensivists believed that central venous pressure should guide resuscitation, 86% used it because of the SSC recommendation [2]. Protocols may improve care, but what should one do when audited patient outcomes are already better than those achieved by guideline interventions – suc...

Sailing in Uncharted Waters: Carefully Navigating the Polio Endgame

In a Perspective linked to the research article by Isobel Blake and colleagues, Elizabeth Miller and T. Jacob John discuss the path towards global polio eradication and the challenges, strategies, and necessary precautions around oral polio vaccine cessation.

Scenarios: Uncharted Waters Ahead

Navigating the uncharted waters of combination therapy in pulmonary arterial hypertension: COMPASS or dead-reckoning.

Despite substantial advances in the treatment of pulmonary arterial hypertension (PAH) over the past two decades, with 13 drugs approved by regulatory agencies worldwide, the responses to medical therapy are often incomplete or unsatisfactory [1]. As with other conditions with complex pathogenesis, PAH is probably the result of multiple stimuli, both genetic and epigenetic, whose interplay over...

Perfecting nerve-sparing radical prostatectomy: sailing in uncharted waters.

I’m not certain where I fi rst heard this expression, but I have lived with the philosophy that if you have been given the privilege to sail in uncharted waters, you have the responsibility to make those charts. I am grateful to Dr. Gabriel Haas, Editor-in-Chief of The Canadian Journal of Urology, for his invitation to discuss my philosophy of discovery. Previously I provided a detailed descrip...